The "intestine is outside the body" part is interesting. If you think about it, that means it's actually "immune" to any PUFA from your own body fat.
So if you stop eating PUFAs today, you'll have all the benefits of a low-PUFA diet pretty much immediately until the point where it enters your bloodstream. From then on out, you're dealing with the memories of PUFA past!
It also makes sense if a lot of HNE is actually produced in there. The heme in the intestines can't oxidize any of the PUFA already in your body fat/blood, right?
I know that beta-oxidation of PUFAs does/can create HNE and other oxidation products in the mitochondria when a fat is burned for fuel. Not sure if there are any other potential oxdiation spots in the body? Is there oxygen around to oxidize?
And no beta-oxidation of LA doesn't cause HNE. Heme in your intestines can't, but your mitochondria make heme proteins, and that's where oxidation can startz, in the membranes where fuels are burned.
The "intestine is outside the body" part is interesting. If you think about it, that means it's actually "immune" to any PUFA from your own body fat.
So if you stop eating PUFAs today, you'll have all the benefits of a low-PUFA diet pretty much immediately until the point where it enters your bloodstream. From then on out, you're dealing with the memories of PUFA past!
It also makes sense if a lot of HNE is actually produced in there. The heme in the intestines can't oxidize any of the PUFA already in your body fat/blood, right?
I know that beta-oxidation of PUFAs does/can create HNE and other oxidation products in the mitochondria when a fat is burned for fuel. Not sure if there are any other potential oxdiation spots in the body? Is there oxygen around to oxidize?
Yeah, explains why my IBS stopped in a couple days after 14 years or so.
And no beta-oxidation of LA doesn't cause HNE. Heme in your intestines can't, but your mitochondria make heme proteins, and that's where oxidation can startz, in the membranes where fuels are burned.