It is a commentry on poor scientific standards in obesity research that papers get published without disclosing the exact fatty acid composition of the diet.
The whole field, from the top down, is irremediably rotten.
I remember Peter@hyperlipid being optimistic about the dogma being overturned 10-15 years ago. But the dogma is still as strong and impregnable as ever.
How do you reconcile the obesigenic quality of lard with the results of the calorie restricted mice with the lard group outliving all the other groups by a wide margin?
My guess would be that PUFAs are preferentially oxidized, so they're probably protected by a calorie deficit, with less PUFA being stored/incorporated into membranes.
Random thought: if these rodents get obese because they lack leptin receptors, doesn't that invalidate the model for humans? Most humans, even obese ones, are perfectly capable of receiving leptin, I think?
Any ideas on how/why it causes leptin resistance? Do you think obese humans have leptin resistance?
Injecting most obese humans with leptin doesn't seem to help (except that tiny minority with the condition), but of course it could be that they have enough leptin, yet the receptor sites are damaged or something.
Similar question for insulin, actually. I still have elevated fasting insulin (usually around 10). Ben Bikman would say eat less crabs, but I'm nearly 10 years into keto, the last 2.5 at 90% fat.
Do you suspect my insulin will just slowly improve as I continue to avoid LA?
Obesity is a Disease and the origin of the World pandemic.The Center for Disease Control and Prevention ( CDC ) have a list of 14 diseases associated with Obesity.
1. Arterial Hypertension
2. Metabolic syndrome
3. Nonalcoholic Steatohepatitis NASH.
4. Type 2 diabetes
5. Various Cancers
6. Heart Attack
7. Brain Stroke
8. Kidney Failure
You can find the others in the CDC website.
Obesity is also a Food Industry with many members that sell PROCESSED FOODS.
Natural fruits and vegetables are not with them. Billions are spent in brain washing the consumers and the people that love the money they receive from Processed Foods Companies (PFC ).
Many physicians, PhD are working for many years trying to prove the association between Processed foods and the Diseases. The first book title : White ,Pure and Deadly. Writen by a British Nutritionist. Sugar is the Deadly food. Medical Associations in the US have also agree with this statement recommending reducing the sugar intake.
The power of the PFC money is the major factor in the pandemic of Obesity and illnesses leading finally to death. But it will change that's for sure very soon.
Yes. I've even tried fasting way more intense than that. Several 5-7 day water fasts, 2 day dry fasts. Maybe the most extreme fasting I did was 5:2 fast:feast (work days vs. weekends) for 2 months. Did not lose any fat.
Great stuff ! Thanks, Tucker.
It is a commentry on poor scientific standards in obesity research that papers get published without disclosing the exact fatty acid composition of the diet.
The whole field, from the top down, is irremediably rotten.
I remember Peter@hyperlipid being optimistic about the dogma being overturned 10-15 years ago. But the dogma is still as strong and impregnable as ever.
As a longtime Hyperlipid reader, I've been trained to always look first at the contents of the diet.
And also, we know that they hardly ever *measure* what's in the diets - they just trust the manufacturers!
Imagine if we had decades of studies with accurate measures of what was in the diets as well as what the outcomes were ...
Yes. All lards are not created equal.
M Malagón (10 May 2025) Vets Are More Diabetic then Civilians? https://open.substack.com/pub/captainmanimalagonusnret/p/vets-are-more-diabetic-than-civiliansl
How do you reconcile the obesigenic quality of lard with the results of the calorie restricted mice with the lard group outliving all the other groups by a wide margin?
My guess would be that PUFAs are preferentially oxidized, so they're probably protected by a calorie deficit, with less PUFA being stored/incorporated into membranes.
Meaning what? The MUFAs on SFAs from the lard are incorporated instead? 🤔
That's right.
Random thought: if these rodents get obese because they lack leptin receptors, doesn't that invalidate the model for humans? Most humans, even obese ones, are perfectly capable of receiving leptin, I think?
Yes, when they first found leptin, they were like, "We've solved obesity!"
Well, only for those who are lacking a leptin receptor, and there are such people.
Note that D12492 causes leptin resistance.
Any ideas on how/why it causes leptin resistance? Do you think obese humans have leptin resistance?
Injecting most obese humans with leptin doesn't seem to help (except that tiny minority with the condition), but of course it could be that they have enough leptin, yet the receptor sites are damaged or something.
Yes, leptin resistance is like insulin resistance, the first symptom is too much in circulation. More doesn't help.
Do you know what causes it?
Similar question for insulin, actually. I still have elevated fasting insulin (usually around 10). Ben Bikman would say eat less crabs, but I'm nearly 10 years into keto, the last 2.5 at 90% fat.
Do you suspect my insulin will just slowly improve as I continue to avoid LA?
Have you tried IF, or aerobic (LISS) exercise, or fasting 1 day a week?
Obesity is a Disease and the origin of the World pandemic.The Center for Disease Control and Prevention ( CDC ) have a list of 14 diseases associated with Obesity.
1. Arterial Hypertension
2. Metabolic syndrome
3. Nonalcoholic Steatohepatitis NASH.
4. Type 2 diabetes
5. Various Cancers
6. Heart Attack
7. Brain Stroke
8. Kidney Failure
You can find the others in the CDC website.
Obesity is also a Food Industry with many members that sell PROCESSED FOODS.
Natural fruits and vegetables are not with them. Billions are spent in brain washing the consumers and the people that love the money they receive from Processed Foods Companies (PFC ).
Many physicians, PhD are working for many years trying to prove the association between Processed foods and the Diseases. The first book title : White ,Pure and Deadly. Writen by a British Nutritionist. Sugar is the Deadly food. Medical Associations in the US have also agree with this statement recommending reducing the sugar intake.
The power of the PFC money is the major factor in the pandemic of Obesity and illnesses leading finally to death. But it will change that's for sure very soon.
Yes. I've even tried fasting way more intense than that. Several 5-7 day water fasts, 2 day dry fasts. Maybe the most extreme fasting I did was 5:2 fast:feast (work days vs. weekends) for 2 months. Did not lose any fat.