Very interesting. I think this should be viewed through an evolutionary sense - we evolved to deal with and use certain LOPs as signaling molecules. Now we're making campfires to create smoke signals, but the atmosphere has been made flammable.
Back to the question in the title: if Peter Dobromylskyj is right about unsaturation affecting the FADH2:NADH ratio, affecting reverse electron flow through complex I, affecting superoxide production, affecting the insulin resistance or insulin sensitivity of adipocytes, then the unsaturation itself is partly responsible for triggering insulin sensitivity and the concomitant obesity and diabetes, right? The double bonds in the PUFA are themselves are enough to open up the one-way street of fat into fat cells.
As you have probably noticed, if you have been reading his recent posts, Peter and I have been going back and forth on this for years trying to sort out what the actual causation is.
I have long suspected that we're both right, and that both phenomena we are focusing on play a role.
Keep watching, hopefully we will figure it out soon!
Thank you so much for this. I had read that omega-3 fats oxidized into less-toxic oxidation products than omega-6 but for the life of me I could not pin down anything definitively comparing the two.
Sorry, I'm commenting based solely on reading the headline and subhead.
"seeds oils are not the problem, it's just oxidization."
"arsenic is not the problem, it's just putting it in your food that's the problem"
The trick is to complete the room-temperature challenge first. In a very cold room.
Very interesting. I think this should be viewed through an evolutionary sense - we evolved to deal with and use certain LOPs as signaling molecules. Now we're making campfires to create smoke signals, but the atmosphere has been made flammable.
Back to the question in the title: if Peter Dobromylskyj is right about unsaturation affecting the FADH2:NADH ratio, affecting reverse electron flow through complex I, affecting superoxide production, affecting the insulin resistance or insulin sensitivity of adipocytes, then the unsaturation itself is partly responsible for triggering insulin sensitivity and the concomitant obesity and diabetes, right? The double bonds in the PUFA are themselves are enough to open up the one-way street of fat into fat cells.
https://high-fat-nutrition.blogspot.com/2012/08/protons-fadh2nadh-ratios-and-mufa.html
So I'm guessing the answer is "both".
As you have probably noticed, if you have been reading his recent posts, Peter and I have been going back and forth on this for years trying to sort out what the actual causation is.
I have long suspected that we're both right, and that both phenomena we are focusing on play a role.
Keep watching, hopefully we will figure it out soon!
Thank you so much for this. I had read that omega-3 fats oxidized into less-toxic oxidation products than omega-6 but for the life of me I could not pin down anything definitively comparing the two.