Ep. 16: Understanding HNE, Biomarkers, and LPO—with Matt Quinn and Dr. Brian Kerley
Ep. 16: Understanding HNE, Biomarkers, and LPO—with Matt Quinn and Dr. Brian Kerley
tldr; All the things that mystify when trying to make sense of one of these studies.
Introduction
We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have.
This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes.
“The study of lipid peroxidation (LPO) processes has become a rapidly growing field in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed]
Asthma
Atherosclerosis
Alzheimer’s disease
Rheumatoid arthritis
Burn injury
Cataractogenesis
Diabetes
Endotoxin liver injury
Multiple sclerosis
Myocardial infarction
Organ transplantation
Parkinson disease
Psoriasis
Reperfusion injury
Stroke
Aging
“The obvious involvement of LPO processes in the majority of severe diseases stimulated worldwide efforts to elucidate the mechanisms of their generation.
“These efforts are expressed in the exploding flood of papers, conference reports, review articles (see above) and books dealing with LPO. This paper is, therefore, not intended to add to these reviews but rather to address aspects previously overlooked: the dominant role of linoleic acid (LA) in LPO and the application of a combination of modern separation and identification techniques to isolate LPO products. Knowledge of these products provides insight into the mechanisms of their generation and offers a better understanding of the diseases in which LPO is involved.” (Spiteller 1998)
Guest info
Matt Quinn
Biography:
TL;DR Here's what I am working on:
I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here
I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this
I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here
In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here
I have failed at so so so many things - read about them here
https://www.mquinn.online/
_______________________________________
Co-host
Dr. Brian Kerley
https://www.seedoilrebellion.com/
https://twitter.com/SeedOilDsrspctr
Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
https://www.seedyapp.com/
Tucker Goodrich
Substack:
Twitter: https://twitter.com/TuckerGoodrich
Youtube: https://www.youtube.com/tuckergoodrich0
Apple podcast:
Spotify podcast:
Podcast: https://sites.libsyn.com/408758
Blog (deprecated, but still a lot there!):
http://yelling-stop.blogspot.com/
_______________________________________
Show Notes
Episode 14 Post Script: Matt Has a Surprising Easter Egg
Spiteller, G. (1998). Linoleic Acid Peroxidation—The Dominant Lipid Peroxidation Process in Low Density Lipoprotein—And Its Relationship to Chronic Diseases. Chemistry and Physics of Lipids, 95(2), 105–162. https://doi.org/10.1016/S0009-3084(98)00091-7
I will watch this when I have a quiet space. It seems very important. One of the things that popped into mind yesterday was foetal development. Mothers using seed oils must be passing some on to the developing child, I don't know the details of how nutrients get passed to the foetus (what the placenta rejects) but if seed oil lipids can get used in cells of those who consume them our bodies must see them as OK. So new little humans are already set up for ill health at birth, which would fit with increasing rates of obesity of infants and older children. This is a crime.
Of possible interest is a new AI model of mitochondrial reactions that was built to predict what molecules would be toxic to the mitochondria as detailed in
Zhang R, Chen Z, Wang B, Li Y, Mu Y, Li X. Modeling and Insights into the Structural Characteristics of Chemical Mitochondrial Toxicity. ACS Omega. 2023 Aug 23;8(35):31675-31682. doi: 10.1021/acsomega.3c01725. PMID: 37692239; PMCID: PMC10483523.
Model is on OCHEM, where you have to create an account or log in as a guest. The model name is Consensus Mitochondrial Toxicity, published by qingshuang0501