Toxic blood

Blood becomes toxic with age. What causes this?

Albumin from a high-linoleic acid diet (my favorite, D12492) contributes to diabetes and beta-cell failure.

"Young and Undamaged Recombinant Albumin Alleviates T2DM by Improving Hepatic Glycolysis Through Egfr and Protecting Islet Β Cells in Mice"

doi.org/10.1186/s12967-023-03957-3

(They’re using recombinant mouse serum albumin—rMSA.)

Undamaged albumin extends lifespan:

"The median lifespan extensions were 17.6% for female and 20.3% for male, respectively.

And, "the grip strength of rMSA-treated female and male mice increased by 29.6% and 17.4%..."

But that's not all! Cognitive function improved:

"Meanwhile, the percentage of successful escape increased 23.0% in rMSA-treated male mice using the Barnes Maze test….

And the treated mice were better-looking:

"Interestingly, mice treated with rMSA had glossier and thicker fur than saline-treated mice (Fig. 1D)."

There's already a company exploring this for humans:

“Young Blood and the Search for Biological Immortality”

“While Alkahest does not disclose the reasoning behind the proteins it chooses for treatment, albumin has been of special interest due to its ability to stabilize other factors, preventing them from degrading. “Albumin is a sponge protein that’s the most abundant protein in the blood,” Wyss-Coray explains. “It binds a lot of different factors and acts as an antioxidant to some extent, and with age, it changes its function and it’s not as effective.”

You’d think folks interested in aging and longevity would be all over that first paper…