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David Brown's avatar

This discussion brought to mind Veterinary epidemiologist Stephanie Venn-Watson who wrote a whole book based on the claim that insulin resistance is driven primarily by a cascade starting with deficiency of the odd‑chain saturated fatty acid C15:0, leading to membrane fragility, ferroptosis‑like lipid peroxidation, and iron overload in the liver and pancreas. Here is some of the evidence she cites:

https://pmc.ncbi.nlm.nih.gov/articles/PMC7235264/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9135213/

https://pmc.ncbi.nlm.nih.gov/articles/PMC10649853/

https://pubmed.ncbi.nlm.nih.gov/39069269/

David Brown's avatar

I wish Dr. Speakman would do a human weight loss trial with LA intake limited to 2% energy or less and with no cap on oleic acid or saturated fatty acid intake in both arms of the trial. For comparison purposes, the other arm would limit both linoleic acid and preformed arachidonic acid intake to ascertain the impact on endocannabinoid tone. https://pmc.ncbi.nlm.nih.gov/articles/PMC10767670/

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